MIC 4100 Pathogens and the Environment (3 units)

Fundamentals of health-related environmental microbiology with particular emphasis on human pathogenic micro-organisms. Includes the interrelationship of micro-organisms with their environment, how environmental factors affect microbial survival, ability to spread and cause diseases. Mechanisms used in the environmental control of human pathogens. To be offered every year subject to sufficient demand. Previously MIC 5500.

Course Component: Lecture

Prerequisite: BIO 3124.

MIC 4124 Pathogenic Bacteriology (3 units)

Comprehensive overview of pathogenic bacteria and mechanisms of pathogenesis. Principles of bacterial pathogenicity, host-parasite interactions, diagnosis and prevention. Physiological relation to mechanisms of pathogenicity, major pathogens and treatment. To be offered every year subject to sufficient demand. Previously MIC 5224.

Course Component: Lecture

Prerequisites: BIO 3124, (BCH 3170 or BIO 3170).

MIC 4125 Immunology (3 units)

Introduction of the fundamental principles of immunology and understanding of the basic immunological reactions. Description of nature and chemistry of antigens, antibodies, antibody-antigen reactions, specific humoral and cellular immune responses. Role of the immune system in infections, control of cancers, transplant rejection, autoimmune diseases and allergy. To be offered every year subject to sufficient demand. Previously MIC 5124.

Course Component: Lecture

Prerequisite: BCH 3170 or BIO 3170.

MIC 4126 Virology (3 units)

Survey of viruses that infect bacteria, plants and animals, emphasizing the basic principles of virus structure, classification and transmission. Examination of molecular mechanisms involved in virus replication and virus-host interactions, using as specific examples, pathogenic viruses that infect humans or animals. To be offered every year subject to sufficient demand. Previously MIC 5326.

Course Component: Lecture

Prerequisite: BCH 3170 or BIO 3170.

MIC 4525 Immunologie (3 crédits)

Introduction des principes fondamentaux de l'immunologie et compréhension des réactions immunologiques de base. Description de la nature et de la chimie des antigènes, des anticorps, des réactions anticorps-antigène, ainsi que des réponses immunitaires humorales et cellulaires. Le rôle du système immunitaire dans les infections, le contrôle des cancers, le rejet de greffe, les maladies auto-immunes et les allergies.

Volet : Cours magistral

Préalable: BCH 3570 ou BIO 3570.

MIC 5100 Pathogen Interactions and Host (3 units)

This course will examine current issues in microbiology/immunology. Topics to be chosen to allow discussion across the broad areas of virology, immunology and bacteriology. Within each of the modules, the focus will be on host-pathogen interactions at the molecular level, how microorganisms utilize, modify or disrupt host cell functions, including immune cell functions and immune responses, to establish infection and cause diseases, or on immunological diseases which may have an infectious component.

Course Component: Lecture

Prerequisite: At least one undergraduate course in microbiology and/or immunology and one course in molecular biology.

MIC 5366 MSc Seminar (3 units)

Attendance at two half-day symposia with guest speakers, attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Microbiology and Immunology. Students must present at least one poster and one oral presentation during the course of their program. Graded S (Satisfactory) or NS (Not satisfactory).

Course Component: Seminar

MIC 6003 Thesis Research in Microbiology and Immunology III

Volet / Course Component: Cours magistral / Lecture

MIC 7999 Thèse de maîtrise / MSc Thesis

Avant la soutenance de sa thèse, il faut que chaque étudiant donne un séminaire portant sur ses recherches au Département. / Prior to defending their thesis, each student will be required to present a formal seminar about their research to the department.

Volet / Course Component: Recherche / Research

MIC 8122 Advanced Topics in Immunology (3 units)

Focus on cellular immunology, including thymocyte maturation, induction and regulation of cellular responses, immune responses to pathogens, immunological memory, tolerance. Student assessments to be conducted by two methods: weekly assessment of student presentations and participation in class discussions; assessment of take-home assignments such as completion of a research grant on a topic covered in the course. To be offered alternate years subject to sufficient demand.

Course Component: Seminar

Prerequisite: MIC 4125.

MIC 8124 Advanced Topics in Cell Death (3 units)

Molecular mechanisms of cell death. Particular attention to be paid to role of aberrant cell death in human disease. Offered in the Fall of odd numbered years.

Course Component: Lecture

MIC 8125 Special Topics in Microbiology and Immunology (3 units)

Discussion of current topics in Microbiology and Immunology. Topics to vary from year to year depending on the interest of faculty members offering the course and students. Student assessments to be conducted by two methods: weekly assessment of student presentations and participation in class discussions; assessment of take-home assignments such as completion of a research grant on a topic covered in the course.

Course Component: Lecture

Prerequisite: Permission of the course coordinator.

MIC 8126 Immunochemistry (3 units)

Focus is on antigen structure of protein and carbohydrate antigens, receptor structure of B cells and T cells, structure of MHC molecules, accessory molecules and cytokine receptors and cell signalling pathways induced by the antigen and cytokine receptors. Student assessments to be conducted by two methods: weekly assessment of student presentations and participation in class discussions; assessment of take-home assignments such as completion of a research grant on a topic covered in the course. To be offered alternate years subject to sufficient demand.

Course Component: Lecture

Prerequisite: MIC 4125.

MIC 8129 Current Topics in Haematopoietic Stem Cells and Immune Development (3 units)

This course will focus on the haematopoietic system that gives rise to the many cell types of the immune system. Topics to be covered include the developmental processes of embryonic stem cell differentiation into mesoderm and then into haematopoietic and non-haematopoietic progenitors; development of adult haematopoietic and immune systems; symmetric and asymmetric division of cells; intrinsic transcription factors and extracellular microenvironment factors regulating cell fate; immunological aspects of stem-cell based therapy; new technologies and their use in the field, and experimental design.

Course Component: Lecture

Prerequisite: At least one undergraduate course in immunology or cell biology.

MIC 8134 Structure and Expression of Eukaryotic and Prokaryotic Genomes (3 units)

Sequencing of eukaryote and prokaryote genomes with emphasis on recent technologies, sequence alignments and databases and assembly of genomes from massively parallel sequencing data. Focus on mapping studies, including linkage disequilibrium-based genome-wide association study (GWAS), to characterize functional variants associated with complex traits. Analysis and structure of microbial metagenomes from environmental and human habitats, including structure-function analysis of microbial communities, microbiota-human disease correlations, and molecular phylogeny. Genome expression, including measures of RNA transcripts and proteins and statistical analysis of data. Combination of various -omics data to understand gene-environment interactions.

Course Component: Lecture

MIC 8236 Advanced Topics in Virology (3 units)

An in-depth presentation of current topics in virological research. Topics will vary from year to year. To be offered every alternate year subject to sufficient demand.

Course Component: Lecture

MIC 8238 Advanced Topics in Bacteriology - Mechanisms of Pathogenesis (3 units)

Recent advances and current topics in selected areas of bacteriology with emphasis on mechanisms of pathogenesis. Students present and discuss journal articles. Offered every alternate year subject to sufficient demand.

Course Component: Lecture

MIC 8241S Seminars II (2 crédits / 2 units)

Every graduate student will be required to attend the weekly departmental seminars. Compulsory for all graduate students.

Volet / Course Component: Cours magistral / Lecture

MIC 8242S Seminars III (2 crédits / 2 units)

Every graduate student will be required to attend the weekly departmental seminars. Compulsory for all graduate students.

Volet / Course Component: Cours magistral / Lecture

MIC 8243S Seminars IV (2 crédits / 2 units)

Every graduate student will be required to attend the weekly departmental seminars. Compulsory for all graduate students.

Volet / Course Component: Cours magistral / Lecture

MIC 8244S Seminars V (2 crédits / 2 units)

Every graduate student will be required to attend the weekly departmental seminars. Compulsory for all graduate students.

Volet / Course Component: Cours magistral / Lecture

MIC 8366 PhD Seminar (3 units)

Attendance at two half-day symposia with guest speakers, attendance and participation in the annual BMI Student Symposium and BMI Poster Day, attendance at BMI seminars relevant to Microbiology and Immunology. Students will present a poster in their first and every alternate year, and an oral presentation the second and every alternate year until they have permission to write their thesis. Graded S (Satisfactory) / NS (Not satisfactory).

Course Component: Seminar

MIC 8401 Advanced Topics in Bacterial Genetics (3 units)

Microbial genetic and genomic methods: origin, purpose and functioning. Analysis and use of genomes to study bacterial pathogenesis and host-microbe interactions.

Course Component: Lecture

Prerequisite: MIC 5224 or equivalent.

MIC 8500 Special Topics in Health- Related Environmental Microbiology (3 crédits)

Recent advances and current topics in selected areas of health-related environmental microbiology. Topics reflect student interest. Offered in alternate years subject to sufficient demand.

Volet : Cours magistral

Prerequisite: MIC 5500 or equivalent.

MIC 8534 Structure et expression des génomes procaryotes et eucaryotes (3 crédits)

Le séquençage des génomes eucaryotes et procaryotes, avec un accent particulier sur les technologies récentes, l'alignement des séquences et les bases de données, et l'assemblage des génomes à partir de données générées par séquençage haut débit. Les études de cartographie comparée incluant les études d'associations pangénomiques basées sur le déséquilibre de liaison pour caractériser les variantes fonctionnelles associées aux traits complexes. L'analyse et la structure de métagénomes microbiens issus d'habitats humains et environnementaux incluant l'analyse structure-fonction des communautés microbiennes, les corrélations entre les maladies humaines et le microbiome ainsi que la phylogénie moléculaire. L'expression génique incluant les mesures de transcriptomes et de protéomes ainsi que l'analyse statistique des données. La combinaison des différentes données omiques pour comprendre les interactions gène-environnement.

Volet : Cours magistral

MIC 8700 Biology and Pathogenesis of HIV Infection (3 crédits)

Biology and pathogenesis of Human Immunodeficiency Virus (HIV) infection. Genetics, replication, structure, regulation of gene expression, immunopathogenesis, antiviral therapy and vaccine development. Offered in alternate years subject to sufficient demand.

Volet : Séminaire

MIC 9998 Examen de synthèse / Comprehensive Examination

Volet / Course Component: Recherche / Research

MIC 9999 Thèse de doctorat / PhD Thesis

Volet / Course Component: Recherche / Research